Birth Defects
Birth defects are structural changes present at birth that can affect almost any part of the body, such as the heart, brain, or foot. They may affect how the body looks, works, or both.
Affects 1 in every 33 babies born in the US each year. Accounting for 20% of all infant deaths, 1 in 5.
For most birth defects, we don’t know what causes them. However, we have learned that some things might increase the chances of having a baby with a birth defect, such as:
smoking, drinking alcohol, or taking certain drugs during pregnancy
having certain medical conditions, such as uncontrolled diabetes
taking certain medications, such as isotretinoin (used to treat acne)
having someone in your family with a birth defect
getting certain infections during pregnancy, such as cytomegalovirus or Zika
having fever greater than 101 degrees F or having elevated body temperature
The age at which you have a child can also influence the risk for birth defects. Some defects are seen more among young mothers whereas the risk for chromosomal malformation defects increases with age. You can still have a baby with a birth defect even if you don’t have any of these known risks, and having one of these risks doesn’t mean that your baby will have a birth defect.
Prenatal screening tests can identify whether your baby is more or less likely to have certain birth defects.
An estimated frequency of birth defects in the United States is as follows:
Defect
Anencephaly
Encephalocele
Spina bifida without anencephaly
Anophthalmia/microphthalmia
Atrioventricular septal defect
Coarctation of the aorta
Common truncus
Double outlet right ventricle
Ebstein anomaly
Hypoplastic left heart syndrome
Interrupted aortic arch
Pulmonary valve atresia and stenosis
Pulmonary valve atresia
Single ventricle
Tetralogy of Fallot
Anomalous pulmonary venous connection
Transposition of the great arteries
Dextro-transposition of great arteries
Tricuspid valve atresia and stenosis
Tricuspid valve atresia
Cleft lip with and without cleft palate
Cleft lip with cleft palate
Cleft lip alone
Cleft palate alone
Clubfoot
Diaphragmatic hernia
Gastroschisis
Limb deficiencies
Omphalocele
Esophageal atresia/tracheoesophageal fistula
Rectal and large intestinal atresia/stenosis
Trisomy 13 (Patau Syndrome)
Trisomy 18 (Edwards Syndrome)
Trisomy 21 (Down Syndrome)
Brain/Spine
Eye
Heart
Mouth/face
Muscle/bone
Stomach/intestine
How many babies are affected each year?
700
354
1278
723
2145
2146
230
867
284
929
365
3779
548
239
1768
486
1097
928
665
325
3560
2320
1240
2321
6850
1143
1506
1779
914
882
1654
527
1101
5713